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Tricyclic Antidepressants (TCA)

The Tricyclic Antidepressants (TCAs) were the first kinds of antidepressants to be developed and used in clinical practice. While they are still available today, they are no longer considered a first choice option because they tend to cause significantly more side-effects and are more lethal in overdose than the newer forms of antidepressants, such as the SSRIs, Bupropion, Duloxetine, Milnacipran, Mirtazapine, Venlafaxine and Desvenlafaxine, while not being more effective.

These days, the TCAs are used mainly for treatment-resistant cases of Depression, and in low doses some of them can also help with insomnia and chronic pain. Desipramine and Imipramine are sometimes used for treating Attention-Deficit/ Hyperactivity Disorder (ADHD), and Clomipramine can be effective for Obsessive-Compulsive Disorder (OCD).

Some of the more commonly used TCAs include: