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Genetic Causes of Schizophrenia

Schizophrenia is more common in individuals who have family members who are also affected by the condition.  While the rate of Schizophrenia in the general population is about 1%, having a first-degree relative with the illness raises a person's risk to 10%, having two parents with Schizophrenia raises a person's risk to over 40%, and having an identical twin with the condition raises one's risk to close to 50% [ref, ref]. These findings suggest that there is an important heritable, or genetic, underpinning of Schizophrenia.

Although various genes have been considered as possibly contributing to Schizophrenia, there is not enough clear cut evidence regarding the influence of any one gene on the condition. It is likely that the condition is a result of the actions of multiple different genes in combination with environmental triggers.

 

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Overview of Causes

Brain Regions