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Treating a Major Depressive Episode associated with Menopause

The following treatment guidelines are meant as a reference tool only, and are not intended as treatment advice or to replace the clinical decision-making process of psychiatrists or other health professionals who administer these treatments. In clinical practice there are often good reasons why treatment approaches differ from what is described here.

Follow the same approach as for treating a Major Depressive Episode. However, Hormone Replacement Therapy (HRT) can be included as an option in Steps 1b, 2a and 2c [ref, ref].  It should be noted, though, that in one study Escitalopram was shown to be superior to HRT for improving both depressive and menopausal symptoms in such women [ref], and HRT can have significant long-term side-effects.


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Premenstrual Dysphoric Disorder (PMDD)

Seasonal Affective Disorder