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Treatment of Depression in Alzheimer's Disease

Depressive symptoms occur very commonly among individuals with Alzheimer's Disease [ref], especially in the first stages of the illness.

Antidepressants have had mixed results, with some studies showing that they do help alleviate depressive symptoms, while others, including some large studies, showing no difference from placebo [ref, ref]. SSRIs would be a first choice for use given their more favorable side-effect profile. Stimulants, such as Methylphenidate or Amphetamine, can also be considered, though supporting evidence is very limited [ref].

There is some evidence that Behavioral Therapy in combination with an exercise program can treat depressive symptoms in Alzheimer's Disease [ref].


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Agitation and Psychosis

Vascular Dementia